Abstract
Influenza vaccination is the best method of control for seasonal influenza outbreak. Vaccination depends on the host’s humoral immunity to clear virus infections. However the dynamics of humoral immunity on controlling the virus titers have been relatively unexplored. Most specifically the qualitative impact of humoral immunity during primary and secondary immune response has not been explored. Here we establish a parsimonious model to study the significance of B cells and antibody that neutralizes virus and terminate infection. We demonstrate the effectiveness of the humoral immune response during a primary infection and see that memory formation is a slow process that may lead to detrimental conditions for the host in the absence of other immune effectors. However once formed memory B cells are highly efficacious in controlling subsequent challenges by the host.
| Original language | American English |
|---|---|
| Title of host publication | Proceedings of the Sixth Symposium on B.E.E.R. |
| Pages | 198-205 |
| Volume | 1 |
| State | Published - 2015 |
Disciplines
- Physical Sciences and Mathematics
- Applied Mathematics