Signal transduction in DC differentiation: winged messengers and Achilles' heel

Inna Lindner; Pedro J. Cejas; Louise M. Carlson; Julie Torruellas Garcia; Gregory V. Plano; Kelvin P. Lee

Signal transduction in DC differentiation: winged messengers and Achilles' heel

Inna Lindner, Pedro J. Cejas, Louise M. Carlson, Julie Torruellas Garcia, Gregory V. Plano, Kelvin P. Lee

Department of Biological Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Dendritic cells (DC) are centrally involved in the initiation and regulation of the adaptive immune response, and different DC can have markedly different (e.g., opposing) function. Acquisition of specific functions is likely to be a result of both nature and nurture, namely differentiation of progenitors into distinct DC subsets as well as the influence of environmental signals. This is not unlike what is seen for T and B cells. This review will focus on the signal transduction pathways that allow an unusually wide range of hematopoietic progenitors to differentiate into DC, the functional characteristics regulated by these pathways, and the ability of pathogens to alter DC function by subverting these pathways during progenitor→DC differentiation.

Original language	American English
Title of host publication	Crossroads between Innate and Adaptive Immunity
Editors	Peter D. Katsikis, Stephen P. Schoenberger, Bali Pulendran
Place of Publication	New York
Publisher	Springer
Chapter	1
Pages	1-29
Volume	590
ISBN (Electronic)	978-0-387-34814-8
ISBN (Print)	978-0-387-34813-1, 978-1-4419-4191-6
State	Published - Dec 6 2006

Publication series

Name	Advances in Experimental Medicine and Biology
ISSN (Print)	0065-2598

Disciplines

Biology

Access to Document

http://link.springer.com/content/pdf/10.1007%2F978-0-387-34814-8_1.pdf

Cite this

Lindner, I., Cejas, P. J., Carlson, L. M., Garcia, J. T., Plano, G. V., & Lee, K. P. (2006). Signal transduction in DC differentiation: winged messengers and Achilles' heel. In P. D. Katsikis, S. P. Schoenberger, & B. Pulendran (Eds.), Crossroads between Innate and Adaptive Immunity (Vol. 590, pp. 1-29). (Advances in Experimental Medicine and Biology). Springer. http://link.springer.com/content/pdf/10.1007%2F978-0-387-34814-8_1.pdf

Signal transduction in DC differentiation: winged messengers and Achilles' heel. / Lindner, Inna; Cejas, Pedro J.; Carlson, Louise M. et al.
Crossroads between Innate and Adaptive Immunity. ed. / Peter D. Katsikis; Stephen P. Schoenberger; Bali Pulendran. Vol. 590 New York: Springer, 2006. p. 1-29 (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lindner, I, Cejas, PJ, Carlson, LM, Garcia, JT, Plano, GV & Lee, KP 2006, Signal transduction in DC differentiation: winged messengers and Achilles' heel. in PD Katsikis, SP Schoenberger & B Pulendran (eds), Crossroads between Innate and Adaptive Immunity. vol. 590, Advances in Experimental Medicine and Biology, Springer, New York, pp. 1-29. <http://link.springer.com/content/pdf/10.1007%2F978-0-387-34814-8_1.pdf>

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title = "Signal transduction in DC differentiation: winged messengers and Achilles' heel",

abstract = " Dendritic cells (DC) are centrally involved in the initiation and regulation of the adaptive immune response, and different DC can have markedly different (e.g., opposing) function. Acquisition of specific functions is likely to be a result of both nature and nurture, namely differentiation of progenitors into distinct DC subsets as well as the influence of environmental signals. This is not unlike what is seen for T and B cells. This review will focus on the signal transduction pathways that allow an unusually wide range of hematopoietic progenitors to differentiate into DC, the functional characteristics regulated by these pathways, and the ability of pathogens to alter DC function by subverting these pathways during progenitor→DC differentiation.",

author = "Inna Lindner and Cejas, {Pedro J.} and Carlson, {Louise M.} and Garcia, {Julie Torruellas} and Plano, {Gregory V.} and Lee, {Kelvin P.}",

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volume = "590",

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T1 - Signal transduction in DC differentiation: winged messengers and Achilles' heel

AU - Lindner, Inna

AU - Cejas, Pedro J.

AU - Carlson, Louise M.

AU - Garcia, Julie Torruellas

AU - Plano, Gregory V.

AU - Lee, Kelvin P.

PY - 2006/12/6

Y1 - 2006/12/6

N2 - Dendritic cells (DC) are centrally involved in the initiation and regulation of the adaptive immune response, and different DC can have markedly different (e.g., opposing) function. Acquisition of specific functions is likely to be a result of both nature and nurture, namely differentiation of progenitors into distinct DC subsets as well as the influence of environmental signals. This is not unlike what is seen for T and B cells. This review will focus on the signal transduction pathways that allow an unusually wide range of hematopoietic progenitors to differentiate into DC, the functional characteristics regulated by these pathways, and the ability of pathogens to alter DC function by subverting these pathways during progenitor→DC differentiation.

AB - Dendritic cells (DC) are centrally involved in the initiation and regulation of the adaptive immune response, and different DC can have markedly different (e.g., opposing) function. Acquisition of specific functions is likely to be a result of both nature and nurture, namely differentiation of progenitors into distinct DC subsets as well as the influence of environmental signals. This is not unlike what is seen for T and B cells. This review will focus on the signal transduction pathways that allow an unusually wide range of hematopoietic progenitors to differentiate into DC, the functional characteristics regulated by these pathways, and the ability of pathogens to alter DC function by subverting these pathways during progenitor→DC differentiation.

UR - https://nsuworks.nova.edu/cnso_bio_facarticles/255

UR - http://link.springer.com/content/pdf/10.1007%2F978-0-387-34814-8_1.pdf

M3 - Conference contribution

SN - 978-0-387-34813-1

SN - 978-1-4419-4191-6

VL - 590

T3 - Advances in Experimental Medicine and Biology

SP - 1

EP - 29

BT - Crossroads between Innate and Adaptive Immunity

A2 - Katsikis, Peter D.

A2 - Schoenberger, Stephen P.

A2 - Pulendran, Bali

PB - Springer

CY - New York

ER -

Signal transduction in DC differentiation: winged messengers and Achilles' heel

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